Ondexxya (andexanet alfa) was approved for the reversal of the anticoagulating effects of rivaroxaban and apixaban in patients with life-threatening or uncontrolled bleeding by: This is the first and only approved antidote for apixaban- or rivaroxaban-treated patients with uncontrolled bleeding.3, The EMA granted approval under conditional marketing authorisation, to support the development of and early access to medicines that address unmet medical needs of patients in the European Union.3, The FDA granted Andexxa with Orphan Drug and Breakthrough Therapy designations, to support the development of medicines which treat a serious or life-threatening condition and fill an unmet medical need.4. Expand to see all locations within your area. Please beware of fraudulent websites, communications and typo deviations used by fraudulent providers claiming to represent TheSocialMedwork. Use this coupon to get this price at any WALMART PHARMACY location. The average cost difference is well over $20,000 or $53,100 when compared to low or high-dose Andexxa to PCC. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. At a cost of $27k – $55k per dose, a 14% 30day mortality, and 10% thrombotic rate in a study excluding the sickest patients and no comparison arm, it is impossible to say if the andexanet alfa is causing this or just the disease process itself. DA: 23 PA: 51 MOZ Rank: 46. Three to four hours after last dosage, participants received either Ondexxya or placebo as a bolus or as a bolus plus a 2-hour infusion.2,3, The main efficacy outcome was the mean percent change in anti–FXa activity, which is a measure of FXa inhibition by the anticoagulant.2,3, Ondexxya rapidly reversed the anticoagulant activity of apixaban and rivaroxaban in healthy participants within minutes after administration and for the duration of infusion.4, Treatment with Ondexxya showed no evidence of clinical toxic effects.4, Please refer to the summary of product characteristics below and in the resource section for comprehensive information about the safety and effectiveness of Ondexxya (andexanet alfa) for the approved indication.5, 1. (4 vials bolus + 5 vials infusion) The recommended dosing of Andexxa is based on the specific FXa inhibitor, dose of FXa inhibitor, and time since the patient's last dose of FXa inhibitor (see Table 2 ). To date, we have assisted patients in over 80 countries to access thousands of life-improving medicines. Collected information will not be shared with any third party and complies with our stated. Generally, our Named Patient support fee, shipping costs and any local tax (if applicable) are not included in the product price that is displayed on our website unless stated otherwise. Andexxa(c) needs to be reconstituted prior to use; the manufacturer recommends slowly injecting 10 mL of water into the vial containing the powder and allowing 3-5 minutes for the powder to dissolve. A bolus and infusion that costs ~$3,000 per 100mg vial – and requires 900mg for a “low dose” protocol or 1,800mg for a “high dose… Make an enquiry for more information. A Study in Older Subject to Evaluate the Safety and Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Rivaroxaban Payments are fully encrypted and secure. Some countries have a government fund providing financial assistance for citizens to access lifesaving medical treatment abroad. Using "cold chain" delivery, specialised medical couriers have temperature regulated boxes and vehicles to ensure that the medicine is uncompromised. FXa is a protein that helps blood clot, and its inhibitors are used to have an anticoagulant (blood-thinning) effect. The free Drugs.com Discount Card works like a coupon and can save you up to A Study in Older Subjects to Evaluate the Safety and Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Apixaban For instructions on reconstitution of the medicinal product before administration, see section 6.6. If you have a question about its approval in a specific country feel free to contact our support team. I truly appreciate their quick, efficient and professional attitude, as well as their patience and superb customer service…”, “I highly recommend TheSocialMedwork. AS LOW AS $2761.60. or obtaining a sample from the doctor's office. You'll find more details highlighted below. We organise the sourcing, shipment and safe delivery of your medicine. The cost for a monthly or yearly treatment of Ondexxya (andexanet alfa) depends on your prescription requirements which includes the dosage in mg and medicine type ( 4 single-use vials). It is available to order as well. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Clinical trial ANNEXXA-A (NCT02207725), last updated on Oct 1, 2018, 4. Dose: slow IV injection, IV dose is dependent on heparin dose given in the last 3-4 hours (1 mg protamine for 100 units heparin), doses not to exceed 50 mg of protamine sulfate in any 10 minute period (can cause severe, hypotensive or anaphylactoid reactions), usually not more than 100 mg in short period (3, 4). The absence of a warning for a given medicine or combination thereof in no way should be construed to indicate that the medicine or combination is safe, effective or appropriate for any given patient. The safety and efficacy of repeat treatment with andexanet has not been established. Generally, we do not support medical insurance, but we do provide you with an invoice after you make the payment that you may send to your medical insurance company so they can reimburse you. You can pay by bank transfer or credit card. The base cost of each medicine is set by the manufacturer. Reduced by 94% in the group that received an andexanet bolus, as compared to the 21% reduction that was seen in the placebo group, in participants receiving Apixaban. This is the first approved antidote for apixaban- or rivaroxaban-treated patients with uncontrolled bleeds. Should you be in doubt, please contact us by email. At the time of writing, andexanet is $22,000 per package of four 200mg vials. You can also pick up your medicine from our partner pharmacy in Amsterdam or our partner pharmacy in Luxembourg after the order has been paid for. The studies involved a total of 148 healthy volunteers that were treated with apaxiban or rivaroxaban.2,3, Participants were given 5 mg of apixaban two times per day, or 20 mg of rivaroxaban once daily. The cost of Kcentra® is $1.27 per unit; a single dose of Kcentra® for an 80 kg patient costs … That is some hefty price tag. Select your preferred country and input your email to receive a step by step guide on how we can help you legally and safely import a medicine that is not approved in your country. Low titers of anti-ANDEXXA antibodies were observed in 26/145 healthy subjects (17%); 6% (9/145) were first observed at Day 30 with 20 subjects (14%) still having titers at the last time point (Days 44 to 48). The European Medicines Agency (EMA), Europe, on April 26, 2019. Followed by administration of a continuous infusion of 4 mg/min for up to 120 minutes (480 mg). Andexanet Alfa (Andexxa) Formulary Review nih.gov Drug Interactions. Andorra, Argentina, Australia, Austria, Azerbaijan, Bahrain, Belarus, Brazil, Bulgaria, Cambodia, Canada, Chile, China, Colombia, Costa Rica, Croatia, Cyprus, Denmark, Dominican Republic, Egypt, Estonia, Finland, France, Georgia, Germany, Ghana, Greece, Guatemala, India, Iraq, Ireland, Israel, Italy, Jamaica, Japan, Jordan, Kenya, Kuwait, Latvia, Lebanon, Libya, Lithuania, Malawi, Mexico, Montenegro, Nepal, Netherlands, New Zealand, Nigeria, Norway, Oman, Pakistan, Paraguay, Peru, Poland, Qatar, Romania, Saudi Arabia, Serbia, Singapore, Slovenia, Spain, Sri Lanka, Sudan, Sweden, Switzerland, United Arab Emirates, United Kingdom, United States, Venezuela, Zimbabwe, Åland Islands, Afghanistan, Albania, Algeria, American Samoa, Angola, Anguilla, Antarctica, Antigua & Barbuda, Armenia, Aruba, Bahamas, Bangladesh, Barbados, Belgium, Belize, Benin, Bermuda, Bhutan, Bolivia, Bosnia & Herzegovina, Botswana, Bouvet Island, British Indian Ocean Territory, British Virgin Islands, Brunei, Burkina Faso, Burundi, Cameroon, Cape Verde, Cayman Islands, Central African Republic, Chad, Christmas Island, Cocos (Keeling) Islands, Comoros, Congo - Brazzaville, Congo - Kinshasa, Cook Islands, Cuba, Czechia, Côte d’Ivoire, Djibouti, Dominica, Ecuador, El Salvador, Equatorial Guinea, Eritrea, Eswatini, Ethiopia, Falkland Islands, Faroe Islands, Fiji, French Guiana, French Polynesia, French Southern Territories, Gabon, Gambia, Gibraltar, Greenland, Grenada, Guadeloupe, Guam, Guernsey, Guinea, Guinea-Bissau, Guyana, Haiti, Heard & McDonald Islands, Honduras, Hong Kong SAR China, Hungary, Iceland, Indonesia, Isle of Man, Jersey, Kazakhstan, Kiribati, Kyrgyzstan, Laos, Lesotho, Liberia, Liechtenstein, Luxembourg, Macao SAR China, Madagascar, Malaysia, Maldives, Mali, Malta, Marshall Islands, Martinique, Mauritania, Mauritius, Mayotte, Micronesia, Moldova, Monaco, Mongolia, Montserrat, Morocco, Mozambique, Myanmar (Burma), Namibia, Nauru, New Caledonia, Nicaragua, Niger, Niue, Norfolk Island, North Korea, North Macedonia, Northern Mariana Islands, Palau, Palestinian Territories, Panama, Papua New Guinea, Philippines, Pitcairn Islands, Portugal, Russia, Rwanda, Réunion, Saint Barthélemy, Samoa, San Marino, Senegal, Seychelles, Sierra Leone, Slovakia, Solomon Islands, Somalia, South Africa, South Georgia & South Sandwich Islands, South Korea, St. Helena, St. Kitts & Nevis, St. Lucia, St. Martin, St. Pierre & Miquelon, St. Vincent & Grenadines, Suriname, Svalbard & Jan Mayen, Syria, São Tomé & Príncipe, Taiwan, Province of China, Tajikistan, Tanzania, Thailand, Timor-Leste, Togo, Tokelau, Tonga, Trinidad & Tobago, Tunisia, Turkmenistan, Turks & Caicos Islands, Tuvalu, U.S. Outlying Islands, U.S. Virgin Islands, Uganda, Ukraine, Uruguay, Uzbekistan, Vanuatu, Vatican City, Vietnam, Wallis & Futuna, Western Sahara, Yemen, Zambia, Iran, Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity Turkey, Dear valued patients and customers, The recommended dosing of Ondexxya is based on the specific FXa inhibitor (apaxiban or rivaroxaban), dose and time since the patient last took the FXa inhibitor.1, Patients being treated with (oral) anticoagulation drugs have underlying disease states which puts them at increased risk of developing thromboembolism. Your order will be shipped to you by our partner couriers, such as DHL, UPS and specialised cold chain couriers. Always consult your treating physician before starting a course of treatment.
Untersuchung Beim Amtsarzt Wegen Dienstunfähigkeit, Dayz Items Duplizieren, Magenta Tv Box Bestellen, Olivenöl Gegen Hautausschlag, Unfall Bogen Heute, Rückstellung Schule Schreiben Kita, Alice In Borderland Arisu Actor, Kita Am Volkspark,